Basically it is another form of farming and requires the same attention to detail and hygiene as any other sort of farming.
Having said that, there are techniques that enable year-round production which have not been widely broadcast, in the interests of commercial advantage.
To date commercial bumblebee production units have been very capital intensive and purpose-built leading to centralised production. While this creates opportunities for economies of scale it has also led to very long distance freighting of hives, with consequent rising of expense as oil becomes more expensive or the market moves, as it did when the Mexican market came to quickly outweigh the Canadian market.
There is also vulnerability for interruption of supply, as was the case after 9/11. In the event of a pandemic of avian flu one can expect radical disruption of such transport.
While the major producers are represented in over 50 countries there are about 10 countries producing hives. Hives are transported form Belgium to Korea and Finland, Canada to Mexico, Israel to China. It is much more sensible to have local production units.